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The issue of safety with multiple exposures has been discussed previously, showing that repeated FUS treatments did not pose additional hazard to the brain tissue in healthy brains 23,24,25

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Toxic levels of methotrexate can be rapidly and effectively decreased by intravenous administration of glucarpidase, which has been shown to induce a 99% or greater sustained reduction of serum methotrexate levels (Widemann 2014)

Isocitrate dehydrogenase 1 is a novel plasma biomarker for the diagnosis of non-small cell lung cancer

The peptide appears to activate cellular stress response pathways that prepare neurons to withstand subsequent insults