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K63-linked ubiquitination, which typically regulates signaling, DNA repair, and autophagy rather than degradation, is frequently altered in PD, AD, and ALS

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Although our in vivo data robustly demonstrate multi-system recovery, the intricate cellular and molecular crosstalk underlying these effects invites further elucidation through reductionist in vitro models

demonstrated that 8-oxoG in the telomeric region has a dual role, either hindering telomerase-mediated elongation when incorporated as 8-oxodGTP or promoting telomerase activity by destabilizing G-quadruplex structures when preexisting in telomere DNA

Shang et al., 2023