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There are several underlying reasons for the methyl trap: the concentration of Hcy drops, oxidative stress inhibits MS, and the drop in [SAM] releases the inhibition of MTHFR, which drives more folate towards the 5mTHF form

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Zinc gluconate supplementation may help reduce oxidative stress and support overall health and well-being.

It may be that the cause of those symptoms is not IBS, but an underlying gut imbalance called SIBO or small intestinal bacterial overgrowth