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Thus, the idea emerged that GLP-1 could be defined as a hormone in the periphery and as a neuromodulator in the central nervous system 7,8,9

Comparison with CRH-induced corticotropin and cortisol secretion

This technology enables extended pharmacological activity through the site-specific conjugation of a cysteine-albuminconjugated Exendin-4 analog (CA-Exendin-4) to the Fc fragment of human immunoglobulin G subclass 4 (IgG4), linked via a flexible peptide spacer (Fig