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The upregulation of interferon-stimulated gene 15 in TECs disrupted mitochondrial homeostasis and triggered the release of mtDNA into the cytosol, which then triggers NLRP3mediated pyroptosis in cyclic GMP-AMP synthase-stimulator of interferon genes pathway (47)

Side effects are primarily gastrointestinal, generally mild to moderate, and often diminish over time with all three medications

HbA1c is the standard measure of average blood sugar over three months

Particularly noteworthy, the present study revealed that ZDHHC12 plays a critical negative regulatory role in the regressive phase of inflammation by promoting the degradation of NLRP3

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