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Here we outline the evolution of incretin-based pharmacotherapy, from exendin-4 to the discovery of the multi-incretin hormone receptor agonists that look set to be our next step toward curing diabetes and obesity

Concurrently, improved glycemic control reduces advanced glycation end products, dampens inflammation, and preserves collagen integrity, highlighting the complex effects on the cutaneous microenvironment

According to NICE guidance, referral to a specialist may be appropriate for people with refractory gout despite urate-lowering therapy, those with tophi, where there is diagnostic uncertainty, or in the presence of significant kidney disease

Contraindications Contraindications have not been identified

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