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Hall, C
The Asp9 forms a hydrogen bond with Arg370, while Ser8 and Ser11 of Tirzepatide form a network of hydrogen bonds involving the receptor residue Glu288, Arg 289, and Asn290
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ATP = adenosine triphosphate
242 Astragaloside IV inhibits the PI3K/Akt/mTOR pathway by upregulating miR-155 expression, thereby preventing apoptosis and enhancing autophagy to alleviate myelin damage in Schwann cells and improve neurological function in DPN rat models
This effect is mediated by the gut hormone GLP-1, which is released after food ingestion and stimulates beta cells to produce more cAMP and secrete more insulin (Doyle and Egan 2007)
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