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Seventy-two percent ( n =88) of all malignant peripheral nerve sheath tumors demonstrated complete loss of staining with the anti-H3K27me3 monoclonal antibody (Figures 1b,2b, 2c and 3b, 3c, 3e, 3f)

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Pfizer reported that while the overall frequency of liver enzyme elevations across the over 1,400 participant safety database of danuglipron was in line with approved agents in the class, a single asymptomatic participant in one of the dose-optimization studies experienced potential drug-induced liver injury that resolved after discontinuation of danuglipron

M., McNally, R