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Patients with slower hepatic clearance or higher body mass may experience longer drug accumulation, making timing deviations more significant
After weighting, the use of GLP-1 receptor agonists was not associated with an increased risk of suicidality compared with DPP-4 inhibitors (weighted incidence rate 3.9 (95% CI 3.5 to 4.4) v 3.7 (3.6 to 3.9) per 1000 person years, respectively
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This suggests that while the warning is in place due to animal data, the actual risk in humans appears to be minimal based on current evidence
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